We’re excited to share our latest in-depth report developed in collaboration with AllMyHealth. This guide provides practical insights on how nutrition plays a vital role in managing Friedreich's ataxia.
Key highlights: understanding Friedreich's ataxia and its impact on nutrition, general dietary guidelines for people with Friedreich's ataxia, specific nutritional needs for Friedreich's ataxia patients, practical advice and meal planning tips (including sample meal plans and recipes).
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In a study by Rowe (2025), researchers investigated brainstem atrophy in patients with Late-Onset GM2-Gangliosidoses (LOGG), which includes late-onset Tay-Sachs (LOTS) and Sandhoff disease (LOSD). Using MRI brain imaging and automatic segmentation, they compared the brainstem substructures of 10 LOGG patients to 7 age-matched controls. They found significant atrophy in the pons and superior cerebellar peduncle (SCP) in LOGG patients compared to controls. Specifically, the pons and SCP volumes were notably smaller in the LOTS subgroup. However, the small size of the LOSD group prevented independent analysis.
Interestingly, there was no clear association between the volume of these brainstem areas and the severity of clinical ataxia or the duration of the disease. The study also referenced previous research by Rowe et al. (2021), which found that cerebellar volume was relatively preserved in LOSD compared to LOTS, where cerebellar atrophy was more pronounced. These findings underscore the importance of distinguishing between LOGG subtypes for a better understanding of the disease's anatomical and clinical manifestations.
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