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In a study by Oubre et al. (2025), eye movements of individuals with ataxia, including those with Friedreich's ataxia, were analyzed during reading to assess oculomotor function. The study involved 102 participants with various ataxias and 70 healthy controls. Using high-frequency binocular gaze tracking, researchers categorized saccades and fixations, summarizing them with statistical features. A linear model correlating these features with ataxia rating scale scores showed high reliability and validity, and was sensitive to disease progression.

Key findings included significant differences in eye movement kinematics across disease severity levels. Notably, the mean angular displacement of fixations, the number and frequency of saccades, and the proportion of regressive saccades were markedly different among participants, indicating the potential of this method to detect subtle oculomotor abnormalities. The study supports the use of quantitative eye movement assessments in clinical trials and suggests their integration into clinical workflows could be beneficial.

Community News

Ataxie Ataxia CanadaAtaxie Ataxia CanadaJan 30, 2025

πŸ‘‹ Hello friends! 😎

Let me introduce myself: Dominique Ruiz-Courcelle, 50% Quebec, 50% Salvadorian, 28 years old, speaks French, English and Spanish, lives in Gatineau πŸ™οΈ, likes to travel ✈️, cinema 🎬, travel, series πŸ“Ί, travel, reading πŸ“š, travel, eating 🍽️, travel, seeing shows 🎀... oh and travel too! 🌍

One thing you should know about me is that I've been roommating with Ataxie de Friedreich since I was 13. πŸ’ͺ I say I live in a roommate because I refuse to let my illness define me! πŸš«πŸ§‘ deuxWe're two separate entities, but we sure have to adapt to each other (actually, I'm not adjusting to her anymore, but oh well πŸ˜…).

Anyway, you'll hear from me at least every month in Ataxie Canada's newsletters πŸ“°, so be prepared to read the stories, sometimes funny πŸ˜‚, sometimes a little less πŸ˜… (but not often, I promise - when asked to rate it out of 10) to my state of health, I always give a 14-15! πŸ˜†) of my life. My goal with this project is to talk to you about it to try to join people like me who live, too, in a roommate with Ataxia. πŸ‘₯ Generally, we all go through similar obstacles πŸ’₯, so why not share my experiences if it can help the world? πŸ™ Also, I dare hope to join some "normal" people πŸ‘€ to show them that sometimes their preconceived (willingly or not) ideas about people with disabilities are totally wrong! πŸš«πŸ€”

Dominique

Ataxie Ataxia Canada Post
Ataxie Ataxia CanadaAtaxie Ataxia CanadaJan 29, 2025

Larimar Therapeutics has announced the start of administration of NOMO-1, its experimental treatment, in adolescents with Friedreich ataxia. This milestone marks a significant advancement in the clinical development of NOMO-1 for this population.

The treatment is administered by intravenous infusion once a week. Participants are monitored for 12 weeks to assess the drug's safety, tolerance and pharmacokinetic effects.

The results of this study will help determine the optimal dose for adolescents and plan for future clinical trials.

Friedreich's ataxia is a rare neurodegenerative condition that affects coordination and balance. NOMO-1 aims to treat the underlying cause of the disease by increasing levels of frataxin, a deficient protein in patients.

This advancement offers hope to patients and their families, especially teens, for whom treatment options are limited.

Sources

https://investors.larimartx.com/news-releases/news-release-details/larimar-therapeutics-announces-dosing-adolescents-nomlabofusp

Ataxie Ataxia Canada Post
Cure FACure FAJan 31, 2025

The FARA Grant Program is proud to award a General Research Grant to Samuel Hasson, PhD, of Rgenta Therapeutics, to develop a way to finely tune frataxin levels in gene therapy approaches for Friedreich’s ataxia (FA).

Learn more about this grant and other FARA-funded research at https://buff.ly/3Wz6Boc.

Cure FA Post

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